Thionyl Chloride → HCID 3715238、化合物

HRID 2210996

反応式

HRID 2210996 の反応式
[OH:1][C:2]1[CH:3]=[C:4]([S:21]([O-:24])(=[O:23])=O)[C:5]2[C:10]([C:11]=1[NH:12][C:13](=O)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2.[NH+:25]1[CH:30]=[CH:29]C=[CH:27][CH:26]=1.S(Cl)(Cl)=O>C1(C)C=CC=CC=1>[CH2:26]([N:25]([CH2:30][CH3:29])[S:21]([C:4]1[C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[C:11]2[N:12]=[C:13]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[O:1][C:2]=2[CH:3]=1)(=[O:24])=[O:23])[CH3:27]

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 19378056pyridinium 3-hydroxy-4-(N-benzoylamino)-1-naphthalenesulfonate

生成物 1

HCID 3715238HCID 3715238、化合物収率 81.6%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A mixture of 3.43 g pyridinium 3-hydroxy-4-(N-benzoylamino)-1-naphthalenesulfonate and 10 ml thionyl chloride was refluxed for 3.5 hours. Toluene (20 ml) was added and the excess thionyl chloride was distilled off with toluene under reduced pressure. The solid residue was dissolved in 50 ml methylene chloride and 10 ml diethylamine was added portionwise while stirring. After 30 min, the reaction mixture was poured into 100 ml ice-water and extracted with 100 ml dichloromethane. The organic phase was separated, washed with water, and dried over sodium sulfate. Evaporation of the solvent gave 2.52 g N,N-diethyl-2-phenylnaphth[1,2-d]oxazole-5-sulfonamide of high purity by NMR. Recrystallization from 95% ethanol gave an analytical sample, m.p. 157° C.

後処理

  1. temperaturewas refluxed for 3.5 hours
  2. distillationthe excess thionyl chloride was distilled off with toluene under reduced pressure
  3. dissolutionThe solid residue was dissolved in 50 ml methylene chloride
  4. addition10 ml diethylamine was added portionwise
  5. additionthe reaction mixture was poured into 100 ml ice-water
  6. extractionextracted with 100 ml dichloromethane
  7. customThe organic phase was separated
  8. washwashed with water
  9. dry with materialdried over sodium sulfate
  10. customEvaporation of the solvent

出典と根拠

ORDレコード
ord-48ba579d39f44eed80357b9ea8c56394
出典データセット
uspto-grants-1995_10
特許番号
US05461155

関連ノート

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