Sodium Hydroxide → HCID 54014973、化合物
反応式
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([C:12]2[CH:16]=[CH:15][S:14][CH:13]=2)=[N:4][N:3]=1.[OH-].[Na+]>CN1CCCC1=O>[C:6]1([C@H:5]([NH:4][C:2]2[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]([C:12]3[CH:16]=[CH:15][S:14][CH:13]=3)=[N:4][N:3]=2)[CH3:12])[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1参加物
4
反応条件
- 温度
- 140 °C
実験手順
510 mg of 1-chloro-4-(3-thienyl)phthalazine and 790 mg of D-α-phenylethylamine were dissolved in 2 ml of N-methylpyrrolidone, and the solution was stirred at 140° C. for 6 hours. After cooling the solution, an aqueous 5% NaOH solution was added to the solution, and the resultant solution was extracted with chloroform. The organic layer was dried, concentrated, purified by silica gel chromatography (eluent: hexane, chloroform, ethyl acetate), and recrystallized from ether to obtain 492 mg of (R)-1-(α-phenylethylamino) -4-(3-thienyl)phthalazine.