Ethyl 2-(2-cyanoanilino)acetate → Ethyl 3-amino-1H-indole-2-carboxylate
反応式
[CH2:1]([O:3][C:4](=[O:15])[CH2:5][NH:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[C:13]#[N:14])[CH3:2].CC(C)([O-])C.[K+]>C1COCC1.[Cl-].[NH4+]>[NH2:14][C:13]1[C:8]2[C:7](=[CH:12][CH:11]=[CH:10][CH:9]=2)[NH:6][C:5]=1[C:4]([O:3][CH2:1][CH3:2])=[O:15]参加物
5
実験手順
To a solution of N-(2-Cyanophenyl)glycine ethyl ester (8.1 g) in THF (125 mL) was added potassium t-butoxide (4.5 g) in one portion with stirring. After 10 min at room temperature the mixture was diluted with saturated ammonium chloride solution and the product was extracted with ether. After drying, over magnesium sulfate the solvent was removed in vacuo and the residue was recrystallized from 80% methanol to afford 3-Amino-2-carboethoxyindole as a tan solid.
後処理
- extractionthe product was extracted with ether
- dry with materialAfter drying, over magnesium sulfate the solvent
- customwas removed in vacuo
- customthe residue was recrystallized from 80% methanol
出典と根拠
- ORDレコード
- ord-b79ec306670a46739f4729534174e271
- 出典データセット
- uspto-grants-1995_10
- 特許番号
- US05463054
反応ノート
読み込み中…