Sodium Azide → 5-(azidomethyl)-2,4(1H,3H)-pyrimidinedione

HRID 2211818

反応式

HRID 2211818 の反応式
[N-:1]=[N+:2]=[N-:3].[Na+].Cl[CH2:6][C:7]1[C:8](=[O:14])[NH:9][C:10](=[O:13])[NH:11][CH:12]=1>CS(C)=O>[N:1]([CH2:6][C:7]1[C:8](=[O:14])[NH:9][C:10](=[O:13])[NH:11][CH:12]=1)=[N+:2]=[N-:3]

参加物

4

反応物 2

HCID 33557Sodium AzideHCID 2361255-(Chloromethyl)uracil

生成物 1

HCID 219630275-(azidomethyl)-2,4(1H,3H)-pyrimidinedione収率 98.5%

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒

実験手順

Sodium azide (0.6 g, 9.34 mmol) was added to a solution of 5-(chloromethyl)-2,4(1H,3H)-pyrimidinedione (0.3 g, 1.67 mmol) in DMSO (5 ml) under nitrogen at room temperature. The reaction was stirred for 2 h then partitioned between ethyl acetate and water. The organic layer was washed with brine, dried over magnesium sulfate and concentrated to give the 5-(azidomethyl)-2,4(1H,3H)-pyrimidinedione (0.275 g, 98%) as a yellow solid.

後処理

  1. customthen partitioned between ethyl acetate and water
  2. washThe organic layer was washed with brine
  3. dry with materialdried over magnesium sulfate
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-22f7f1367d0f4603af5b503bf3ddbb77
出典データセット
uspto-grants-2006_09
特許番号
US07101883B2

関連ノート

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