Chloroform → HCID 21962095、化合物

HRID 2211845ノート

反応式

HRID 2211845 の反応式
[C:1]([N:5]([CH2:11][CH2:12][C:13]#[N:14])[C:6](=[O:10])[C:7](=O)[CH3:8])([CH3:4])([CH3:3])[CH3:2].C(Cl)(Cl)Cl.[H][H]>C(O)C.[Pt]=O>[C:1]([N:5]1[CH2:11][CH2:12][CH2:13][NH:14][CH:7]([CH3:8])[C:6]1=[O:10])([CH3:4])([CH3:3])[CH3:2]

参加物

6

反応物 3

HCID 6212ChloroformHCID 21962097HCID 21962097、化合物HCID 178418361HCID 178418361、化合物

生成物 1

HCID 21962095HCID 21962095、化合物

試薬・触媒・溶媒 2

HCID 82844Platinum oxide (PtO)触媒HCID 702Ethanol溶媒

実験手順

N-(tert-butyl)-N-(2-cyanoethyl)-2-oxopropanamide obtained in Step A (440 mg) and platinum oxide (60 mg) were suspended in ethyl alcohol (40 mL) containing chloroform (0.3 mL) and mixed on a Parr shaker over an atmosphere of hydrogen at 40 psi for 16 h. The mixture was filtered, the catalyst was washed with methanol/dichloromethane (10:90) and the combined filtrate was evaporated and purified by Biotage® flash chromatography (silica gel, 5–10% methanol/dichloromethane) to yield the desired product.

後処理

  1. filtrationThe mixture was filtered
  2. washthe catalyst was washed with methanol/dichloromethane (10:90)
  3. customthe combined filtrate was evaporated
  4. custompurified by Biotage® flash chromatography (silica gel, 5–10% methanol/dichloromethane)

出典と根拠

ORDレコード
ord-eb29f6ab253c41ada1be9eb44108c7da
出典データセット
uspto-grants-2006_09
特許番号
US07101871B2

反応ノート

読み込み中…