Sodium Hydroxide → (5-Methyl-2-pyridin-3-yl-1,3-oxazol-4-yl)acetic acid
反応式
[OH-].[Li+].[CH3:3][C:4]1[O:8][C:7]([C:9]2[CH:10]=[N:11][CH:12]=[CH:13][CH:14]=2)=[N:6][C:5]=1[CH2:15][C:16]([OH:18])=[O:17].[OH-].[Na+]>C(O)C>[CH3:3][C:4]1[O:8][C:7]([C:9]2[CH:10]=[N:11][CH:12]=[CH:13][CH:14]=2)=[N:6][C:5]=1[CH2:15][C:16]([OH:18])=[O:17]参加物
4
反応条件
- 温度
- 22 °C
実験手順
(5-Methyl-2-pyridin-3-yl-1,3-oxazol4-yl)acetic acid lithium hydroxide (12 mg) added. The mixture was stirred at 22° C. for 17 h and heated at 60° C. for 2 h. Ethanol (3 ml) and 2N aqueous sodium hydroxide (1 ml) were added, and stirring was continued at 22° C. for 2 h. The mixture was applied to a sulphonic acid ion exchange cartridge (10 g Isolute SCX) and eluted with methanol followed by 10% triethylamine in methanol. Evaporation of the triethylamine containing fraction gave the title compound as a gum (46 mg).