3-(4-Benzyloxy-phenyl)-3-hydroxy-2-methyl-propionic acid methyl ester → 3-Hydroxy-3-(4-hydroxy-phenyl)-2-methyl-propionic acid methyl ester

HRID 2212565ノート

反応式

HRID 2212565 の反応式
[CH3:1][O:2][C:3](=[O:22])[CH:4]([CH3:21])[CH:5]([C:7]1[CH:12]=[CH:11][C:10]([O:13]CC2C=CC=CC=2)=[CH:9][CH:8]=1)[OH:6].[H][H]>CO.[Pd]>[CH3:1][O:2][C:3](=[O:22])[CH:4]([CH3:21])[CH:5]([OH:6])[C:7]1[CH:12]=[CH:11][C:10]([OH:13])=[CH:9][CH:8]=1

参加物

5

反応物 2

HCID 695964413-(4-Benzyloxy-phenyl)-3-hydroxy-2-methyl-propionic acid methyl esterHCID 178418361HCID 178418361、化合物

生成物 1

HCID 623934773-Hydroxy-3-(4-hydroxy-phenyl)-2-methyl-propionic acid methyl ester収率 104.6%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

10% Pd/C was added to a degassed solution of 3-(4-benzyloxy-phenyl)-3-hydroxy-2-methyl-propionic acid methyl ester (0.335 g, 1.1 mmol) in methanol (30 mL) and charged to 50 PSI hydrogen, then shaken for 2.5 h. The reaction was filtered to remove the catalyst and concentrated to give 3-hydroxy-3-(4-hydroxy-phenyl)-2-methyl-propionic acid methyl ester (0.242 g, 100%) as an oil. MS found: (M+H)+=211.

後処理

  1. filtrationThe reaction was filtered
  2. customto remove the catalyst
  3. concentrationconcentrated

出典と根拠

ORDレコード
ord-91687b1e531340e6bd403277c77ffb25
出典データセット
uspto-grants-2006_09
特許番号
US07102008B2

反応ノート

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