Benzene → Methyl 2-nitrobenzoate

HRID 221294

反応式

HRID 221294 の反応式
[N+:1]([C:4]1[C:9]([C:10]([OH:12])=[O:11])=[CH:8][CH:7]=[CH:6][CH:5]=1)([O-:3])=[O:2].S(Cl)(Cl)=O.[CH:17]1C=CC=CC=1>>[CH3:17][O:11][C:10](=[O:12])[C:9]1[C:4]([N+:1]([O-:3])=[O:2])=[CH:5][CH:6]=[CH:7][CH:8]=1

参加物

4

反応物 3

HCID 241BenzeneHCID 110872-Nitrobenzoic acidHCID 24386Thionyl Chloride

生成物 1

HCID 69072Methyl 2-nitrobenzoate

実験手順

A solution of 6-nitro-benzoic acid in benzene was treated with thionyl chloride (2.5 eq) and stirred at reflux for 8 h. After evaporation, the residue was dissolved in chloroform and then treated with methanol. After stirring at reflux for 3 h, the mixture was evaporated to afford compound 3.

後処理

  1. temperatureat reflux for 8 h
  2. customAfter evaporation
  3. dissolutionthe residue was dissolved in chloroform
  4. additiontreated with methanol
  5. stirringAfter stirring
  6. temperatureat reflux for 3 h
  7. customthe mixture was evaporated

出典と根拠

ORDレコード
ord-2649cd5afe83494992b3eede9c75d02b
出典データセット
uspto-grants-2012_06
特許番号
US08207153B2

関連ノート

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