Sulfuric Acid → 2-(3-Methoxy-4-pyridin-2-ylphenyl)pyrazolo[1,5-a]pyridine

HRID 2213102ノート

反応式

HRID 2213102 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:15]2[C:23](C(OCC)=O)=[C:18]3[CH:19]=[CH:20][CH:21]=[CH:22][N:17]3[N:16]=2)[CH:6]=[CH:7][C:8]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=1.S(=O)(=O)(O)O>C(=O)([O-])[O-].[Na+].[Na+]>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:15]2[CH:23]=[C:18]3[CH:19]=[CH:20][CH:21]=[CH:22][N:17]3[N:16]=2)[CH:6]=[CH:7][C:8]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=1

参加物

4

反応物 2

HCID 1118Sulfuric AcidHCID 21956522HCID 21956522、化合物

生成物 1

HCID 103801282-(3-Methoxy-4-pyridin-2-ylphenyl)pyrazolo[1,5-a]pyridine

試薬・触媒・溶媒 1

HCID 10340Sodium Carbonate溶媒

反応条件

温度
100 °C

実験手順

Ethyl 2-(3-methoxy-4-pyridin-2-ylphenyl)pyrazolo[1,5-a]pyridin-3-carboxylate (25 mg, 0.013 mmol) was treated with 40% sulfuric acid (1 mL), and the reaction mixture was heated to 100° C. for 12 h. The cooled reaction mixture was diluted with a solution of saturated aqueous sodium carbonate (25 mL), and the product was extracted into CH2Cl2 (3×20 mL), dried (MgSO4) and concentrated to afford 2-(3-methoxy-4-pyridin-2-ylphenyl)pyrazolo[1,5-a]pyridine.

後処理

  1. customThe cooled reaction mixture
  2. extractionthe product was extracted into CH2Cl2 (3×20 mL)
  3. dry with materialdried (MgSO4)
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-fe32b9dc06a34722be237a023721bf3c
出典データセット
uspto-grants-2006_09
特許番号
US07105533B2

反応ノート

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