Water → tert-Butyl ((1H-benzo[d]imidazol-2-yl)methyl)carbamate

HRID 2213148

反応式

HRID 2213148 の反応式
O(C)[Na].[C:4]([CH2:6][NH:7][C:8](=[O:14])[O:9][C:10]([CH3:13])([CH3:12])[CH3:11])#[N:5].Cl.Cl.[C:17]1(N)[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[NH2:23].O>CO>[NH:5]1[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[N:23]=[C:4]1[CH2:6][NH:7][C:8](=[O:14])[O:9][C:10]([CH3:11])([CH3:13])[CH3:12]

参加物

6

反応物 4

HCID 962WaterHCID 119901,2-Phenylenediamine dihydrochlorideHCID 545844tert-butyl N-(cyanomethyl)carbamateHCID 178418582HCID 178418582、化合物

生成物 1

HCID 11448004tert-Butyl ((1H-benzo[d]imidazol-2-yl)methyl)carbamate

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

3.32 g of a 30% NaOCH3 solution were added to tert-butyl cyanomethylcarbamate (3 g; 19.21 mmol) in 20 ml of CH3OH, and the mixture was stirred at room temperature for 1 h. After addition of 3.4 g of 1,2-phenylenediamine bishydrochloride, the reaction mixture was stirred further overnight and then added to 100 ml of H2O, and the resulting solid was filtered off and dried in vacuo.

後処理

  1. stirringthe reaction mixture was stirred further overnight
  2. filtrationthe resulting solid was filtered off
  3. customdried in vacuo

出典と根拠

ORDレコード
ord-dbbdafbfa47c4854b58d80974b580e8b
出典データセット
uspto-grants-2006_09
特許番号
US07105508B1

関連ノート

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