関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 2,3-Diaminopyridine | HCID 9956 | — |
| 反応物 | N-Acetyl-L-Cysteine | HCID 12035 | — |
| 反応物 | tert-butyl N-(cyanomethyl)carbamate | HCID 545844 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | tert-Butyl ((1H-imidazo[4,5-b]pyridin-2-yl)methyl)carbamate | HCID 178453115 | 87.8% |
反応手順
A mixture of tert-butyl cyanomethylcarbamate (1.61 g; 10 mmol), 2,3-diaminopyridine (0.56 g; 5 mmol), N-acetylcysteine (1.68 g; 10 mmol) in 10 ml of CH3OH was heated at 50° C. for 89 h. It was then concentrated, and the residue was taken up in a little CH3OH and filtered through an acidic ion exchanger (acetate on polymeric support). Renewed concentration and chromatography on silica gel (CH2Cl2/CH3OH 5%) afforded 1.09 g of the required product;
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07105508B1 |
|---|
| 出典データセット | uspto-grants-2006_09 |
|---|
| ORD ID | ord-c8b53dbe03cc4e3eb75c8e152d878f09 |
|---|
| 出典メモ | uspto-grants-2006_09 |
|---|
