Water → tert-Butyl [4-(1H-benzimidazol-2-yl)-1,3-thiazol-2-yl]methyl-carbamate

HRID 2213151

反応式

HRID 2213151 の反応式
O(C)[Na].[C:4]([C:6]1[N:7]=[C:8]([CH2:11][NH:12][C:13](=[O:19])[O:14][C:15]([CH3:18])([CH3:17])[CH3:16])[S:9][CH:10]=1)#[N:5].Cl.Cl.[C:22]1(N)[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[NH2:28].O>CO>[NH:5]1[C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=2[N:28]=[C:4]1[C:6]1[N:7]=[C:8]([CH2:11][NH:12][C:13](=[O:19])[O:14][C:15]([CH3:16])([CH3:18])[CH3:17])[S:9][CH:10]=1

参加物

6

反応物 4

HCID 962WaterHCID 119901,2-Phenylenediamine dihydrochlorideHCID 22560011Tert-butyl ((4-cyanothiazol-2-YL)methyl)carbamateHCID 178418582HCID 178418582、化合物

生成物 1

HCID 86760240tert-Butyl [4-(1H-benzimidazol-2-yl)-1,3-thiazol-2-yl]methyl-carbamate

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

In analogy to the preparation of 8, 1.89 g of a 30% NaOCH3 solution were added to tert-butyl (4-cyano-1,3-thiazol-2-yl)methylcarbamate (2.5 g; 10.45 mmol) in 25 ml of CH3OH, and the mixture was stirred at room temperature for 2 h. Addition of 1.9 g of 1,2-phenylenediamine bishydrochloride was followed by stirring overnight, and then the reaction mixture was added to 100 ml of H2O, and the solid resulting after filtration was dried in vacuo.

後処理

  1. stirringby stirring overnight
  2. customthe solid resulting
  3. filtrationafter filtration
  4. customwas dried in vacuo

出典と根拠

ORDレコード
ord-f5ebaded0d65491ca59edccccd7fba4b
出典データセット
uspto-grants-2006_09
特許番号
US07105508B1

関連ノート

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