Dimethylformamide → 5-Ureidoindolin-2-one
反応式
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[CH2:5]2.C[N:13](C)[CH:14]=[O:15].C[Si](N=C=O)(C)C>O1CCCC1>[NH:1]([C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[CH2:5]2)[C:14]([NH2:13])=[O:15]参加物
5
実験手順
To a solution of 5-aminoindolin-2-one (8.76, 58.79 mmol) in tetrahydrofuran:dimethylformamide (400 mL:60 mL) was added trimethylsilylisocyanate (10.6 mL, 78.68 mmol) dropwise. The reaction mixture was stirred at ambient temperature for 18 hours. A tan-colored solid formed which was isolated by filtration, washed with ether and dried in vacuo to afford 5-ureidoindolin-2-one (8.5 g).
後処理
- customA tan-colored solid formed which
- customwas isolated by filtration
- washwashed with ether
- customdried in vacuo
出典と根拠
- ORDレコード
- ord-6fa50aaa7623420ab11d234df0210d7a
- 出典データセット
- uspto-grants-2006_09
- 特許番号
- US07105563B2
反応ノート
読み込み中…