Tetrahydrofuran → 4-(1-Hydroxyethyl)-1-(dimethylethoxycarbonyl)imidazole
反応式
[CH3:1][C:2]([CH3:14])([O:4][C:5]([N:7]1[CH:11]=[C:10]([CH:12]=[O:13])[N:9]=[CH:8]1)=[O:6])[CH3:3].O1CCC[CH2:16]1>>[OH:13][CH:12]([C:10]1[N:9]=[CH:8][N:7]([C:5]([O:4][C:2]([CH3:14])([CH3:1])[CH3:3])=[O:6])[CH:11]=1)[CH3:16]参加物
3
実験手順
To a solution of 1-(dimethylethoxycarbonyl)imidazole-4-carboxaldehyde (9.3 g, 47 mmol) in tetrahydrofuran (200 mL) was added a methyl Grignard reagent (6.6 mL, 50 mmol) at ambient temperature. The resulting reaction mixture was stirred overnight at ambient temperature. The reaction was quenched with water and extracted with ethyl acetate. The organic layer was dried (Na2SO4) and concentrated to afford 10 g of 4-(1-hydroxyethyl)-1-(dimethylethoxycarbonyl)imidazole as an oil.
後処理
- customThe resulting reaction mixture
- customThe reaction was quenched with water
- extractionextracted with ethyl acetate
- dry with materialThe organic layer was dried (Na2SO4)
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-1272e2970fe64025ad7a0ca46b3d227f
- 出典データセット
- uspto-grants-2006_09
- 特許番号
- US07105563B2
反応ノート
読み込み中…