4-(1-Hydroxyethyl)-1-(dimethylethoxycarbonyl)imidazole → tert-butyl 4-acetyl-1H-imidazole-1-carboxylate
反応式
[OH:1][CH:2]([C:4]1[N:5]=[CH:6][N:7]([C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])[CH:8]=1)[CH3:3]>C(Cl)Cl.O=[Mn]=O>[C:2]([C:4]1[N:5]=[CH:6][N:7]([C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])[CH:8]=1)(=[O:1])[CH3:3]参加物
4
実験手順
4-(1-Hydroxyethyl)-1-(dimethylethoxycarbonyl)imidazole (8.7 g, 41 mmol) was dissolved in methylene chloride (100 mL) and MnO2 (10.7 g, 123 mmol) was added. The resulting reaction mixture was stirred overnight at ambient temperature. The reaction mixture was filtered, concentrated, and purified with silica column chromatography to afford 4 g of 4-acetyl-1-(dimethylethoxycarbonyl)imidazole and unreacted starting material.
後処理
- customThe resulting reaction mixture
- filtrationThe reaction mixture was filtered
- concentrationconcentrated
- custompurified with silica column chromatography
出典と根拠
- ORDレコード
- ord-fee662d6d17347dd8b9e68680efda31c
- 出典データセット
- uspto-grants-2006_09
- 特許番号
- US07105563B2
反応ノート
読み込み中…