Ethyl 3-methoxy-4-(3-morpholinopropoxy)-6-nitrobenzoate → Ethyl 3-methoxy-4-(3-morpholinopropoxy)-6-aminobenzoate

HRID 2213860ノート

反応式

HRID 2213860 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]([N+:24]([O-])=O)=[CH:12][C:13]=1[O:14][CH2:15][CH2:16][CH2:17][N:18]1[CH2:23][CH2:22][O:21][CH2:20][CH2:19]1)[C:6]([O:8][CH2:9][CH3:10])=[O:7]>[Pd].C(O)C.C(OCC)(=O)C>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]([NH2:24])=[CH:12][C:13]=1[O:14][CH2:15][CH2:16][CH2:17][N:18]1[CH2:19][CH2:20][O:21][CH2:22][CH2:23]1)[C:6]([O:8][CH2:9][CH3:10])=[O:7]

参加物

5

反応物 1

HCID 11773033Ethyl 3-methoxy-4-(3-morpholinopropoxy)-6-nitrobenzoate

生成物 1

HCID 11809903Ethyl 3-methoxy-4-(3-morpholinopropoxy)-6-aminobenzoate収率 100.4%

試薬・触媒・溶媒 3

HCID 23938Palladium触媒HCID 702Ethanol溶媒HCID 8857Ethyl Acetate溶媒

実験手順

A suspension of ethyl 3-methoxy-4-(3-morpholinopropoxy)-6-nitrobenzoate (132.2 g, 359 mmol) and 10% palladium on carbon (3.0 g) in a mixture of ethanol (200 ml) and ethyl acetate (2000 ml) was stirred under an atmosphere of hydrogen for 18 hours. Removal of the catalyst by filtration, followed by solvent evaporation in vacuo yielded ethyl 3-methoxy-4-(3-morpholinopropoxy)-6-aminobenzoate (122 g, 100% yield) as a brown oil:

後処理

  1. customRemoval of the catalyst
  2. filtrationby filtration
  3. customfollowed by solvent evaporation in vacuo

出典と根拠

ORDレコード
ord-324bca43eb004ec18ed791767362722b
出典データセット
uspto-grants-2006_09
特許番号
US07105669B1

反応ノート

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