Water → HCID 13173800、化合物

HRID 221400

反応式

HRID 221400 の反応式
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([N+:11]([O-:13])=[O:12])[CH:6]=1)=[O:4].[CH3:14][C:15]([O-:17])=[O:16].[Na+].O>CC(CC)=O>[C:15]([O:17][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([N+:11]([O-:13])=[O:12])[CH:6]=1)=[O:4])(=[O:16])[CH3:14]

参加物

5

反応物 3

HCID 962WaterHCID 752132-Bromo-1-(3-nitrophenyl)ethan-1-oneHCID 517045Sodium Acetate

生成物 1

HCID 13173800HCID 13173800、化合物収率 87.5%

試薬・触媒・溶媒 1

HCID 6569Methyl Ethyl Ketone溶媒

実験手順

2-Bromo-1-(3-nitrophenyl)ethanone (25 g) was dissolved in methylethyl ketone (150 mL). NaOAc (12.5 g) was added and the mixture stirred for 48 hours. Water (100 mL) was added and the reaction mixture extracted with DCM. The DCM layer was dried over Na2SO4 and concentrated to give the title compound (20 g, 87%).

後処理

  1. extractionthe reaction mixture extracted with DCM
  2. dry with materialThe DCM layer was dried over Na2SO4
  3. concentrationconcentrated

出典と根拠

ORDレコード
ord-125495b67b2042a49067997dd3748cf8
出典データセット
uspto-grants-2012_06
特許番号
US08207167B2

関連ノート

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