p-Bromobenzenesulfonyl chloride → 3-{[(4-Bromophenyl)sulfonyl]amino}-2-methylbenzoic acid

HRID 221414

反応式

HRID 221414 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8](Cl)(=[O:10])=[O:9])=[CH:4][CH:3]=1.[NH2:12][C:13]1[C:14]([CH3:22])=[C:15]([CH:19]=[CH:20][CH:21]=1)[C:16]([OH:18])=[O:17]>N1C=CC=CC=1>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:12][C:13]2[C:14]([CH3:22])=[C:15]([CH:19]=[CH:20][CH:21]=2)[C:16]([OH:18])=[O:17])(=[O:10])=[O:9])=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 7396p-Bromobenzenesulfonyl chlorideHCID 27336993-Amino-2-methylbenzoic acid

生成物 1

HCID 29734663-{[(4-Bromophenyl)sulfonyl]amino}-2-methylbenzoic acid

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

The title compound was prepared using a method analogous to Method A, using 4-bromobenzene sulfonyl chloride, 3-amino-2-methylbenzoic acid, and a large excess of pyridine. The title compound was precipitated on partition of the reaction mixture between dilute HCl and DCM. The precipitate was collected by filtration, dissolved in ethyl acetate and dried. Evaporation of the solvent gave the title compound as a pale brown solid.

後処理

  1. customThe title compound was prepared
  2. customThe title compound was precipitated
  3. customon partition of the reaction mixture between dilute HCl and DCM
  4. filtrationThe precipitate was collected by filtration
  5. dissolutiondissolved in ethyl acetate
  6. customdried
  7. customEvaporation of the solvent

出典と根拠

ORDレコード
ord-b1f5b7534e04422fa63ba9a6169bfcbe
出典データセット
uspto-grants-2012_06
特許番号
US08207167B2

関連ノート

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