4-amino-1-benzyl-3-nitro-1H-pyridin-2-one → 3,4-diamino-1-benzyl-1H-pyridin-2-one

HRID 2214449ノート

反応式

HRID 2214449 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][N:5]([CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[C:4](=[O:15])[C:3]=1[N+:16]([O-])=O>O1CCCC1.[Pt]=O>[CH2:8]([N:5]1[CH:6]=[CH:7][C:2]([NH2:1])=[C:3]([NH2:16])[C:4]1=[O:15])[C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1

参加物

4

反応物 1

HCID 219476414-amino-1-benzyl-3-nitro-1H-pyridin-2-one

生成物 1

HCID 219476293,4-diamino-1-benzyl-1H-pyridin-2-one

試薬・触媒・溶媒 2

HCID 82844Platinum oxide (PtO)触媒HCID 8028Tetrahydrofuran溶媒

実験手順

3.9 g (15.9 mmol) of 4-amino-1-benzyl-3-nitro-pyridin-2-one, dissolved in 250 ml of tetrahydrofuran, were hydrogenated over platinum oxide at 50 psi of H2 pressure and at ambient temperature. After the catalyst had been filtered off the filtrate was concentrated by evaporation and the residue was further processed in crude form.

後処理

  1. filtrationAfter the catalyst had been filtered off the filtrate
  2. concentrationwas concentrated by evaporation

出典と根拠

ORDレコード
ord-f674d1a0772a4efb9347181944e7969b
出典データセット
uspto-grants-2006_09
特許番号
US07109192B2

反応ノート

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