Lithium Hydroxide → (S)-3-{4-[2-(2-tert-butyl-5-methyl-oxazol-4-yl)-ethoxy]-2,6-dimethyl-phenyl}-2-ethoxy-propionic acid
反応式
C[O:2][C:3](=[O:30])[C@@H:4]([O:27][CH2:28][CH3:29])[CH2:5][C:6]1[C:11]([CH3:12])=[CH:10][C:9]([O:13][CH2:14][CH2:15][C:16]2[N:17]=[C:18]([C:22]([CH3:25])([CH3:24])[CH3:23])[O:19][C:20]=2[CH3:21])=[CH:8][C:7]=1[CH3:26].[Li+].[OH-]>>[C:22]([C:18]1[O:19][C:20]([CH3:21])=[C:16]([CH2:15][CH2:14][O:13][C:9]2[CH:10]=[C:11]([CH3:12])[C:6]([CH2:5][C@H:4]([O:27][CH2:28][CH3:29])[C:3]([OH:30])=[O:2])=[C:7]([CH3:26])[CH:8]=2)[N:17]=1)([CH3:24])([CH3:25])[CH3:23]参加物
3
実験手順
In analogy to the procedure described in example 46 d], (S)-3-{4-[2-(2-tert-butyl-5-methyl-oxazol-4-yl)-ethoxy]-2,6-dimethyl-phenyl}-2-ethoxy-propionic acid methyl ester was treated with LiOH to obtain (S)-3-{4-[2-(2-tert-butyl-5-methyl-oxazol-4-yl)-ethoxy]-2,6-dimethyl-phenyl}-2-ethoxy-propionic acid as colorless liquid.
後処理
- customdescribed in example 46 d