7-Nitrobenzo[d][1,3]dioxole-4-carboxylic acid → 7-Amino-1,3-dioxaindane-4-carboxylic acid

HRID 2215478ノート

反応式

HRID 2215478 の反応式
[N+:1]([C:4]1[C:9]2[O:10][CH2:11][O:12][C:8]=2[C:7]([C:13]([OH:15])=[O:14])=[CH:6][CH:5]=1)([O-])=O.[H][H]>C(O)C.[Pd]>[NH2:1][C:4]1[C:9]2[O:10][CH2:11][O:12][C:8]=2[C:7]([C:13]([OH:15])=[O:14])=[CH:6][CH:5]=1

参加物

5

反応物 2

HCID 219488047-Nitrobenzo[d][1,3]dioxole-4-carboxylic acidHCID 178418361HCID 178418361、化合物

生成物 1

HCID 219488227-Amino-1,3-dioxaindane-4-carboxylic acid収率 98.7%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

8.05 g of 7-nitro-benzo[1,3]dioxole-4-carboxylic acid is reacted with hydrogen in 650 ml of ethanol with 800 mg of palladium/carbon catalyst under normal pressure at room temperature. It is filtered through diatomaceous earth and concentrated by evaporation in a vacuum. 6.82 g of 7-amino-benzo[1,3]dioxole-4-carboxylic acid is obtained as a brown solid, flash point 196–197° C.

後処理

  1. filtrationIt is filtered through diatomaceous earth
  2. concentrationconcentrated by evaporation in a vacuum

出典と根拠

ORDレコード
ord-41313740138d4377a35fdcefe0c01ea5
出典データセット
uspto-grants-2006_09
特許番号
US07109212B2

反応ノート

読み込み中…