Triethylamine → 2-Chloro-6-(4-chlorobenzylamino)purine

HRID 2215650ノート

反応式

HRID 2215650 の反応式
[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([NH:6][CH:7]=[N:8]2)=[C:4](Cl)[N:3]=1.C(N(CC)CC)C.[Cl:19][C:20]1[CH:27]=[CH:26][C:23]([CH2:24][NH2:25])=[CH:22][CH:21]=1>C(O)C>[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([NH:6][CH:7]=[N:8]2)=[C:4]([NH:25][CH2:24][C:23]2[CH:26]=[CH:27][C:20]([Cl:19])=[CH:21][CH:22]=2)[N:3]=1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 660364-ChlorobenzylamineHCID 53244122,6-Dichloropurine

生成物 1

HCID 219518362-Chloro-6-(4-chlorobenzylamino)purine

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
80 °C

実験手順

To a suspension of 15 g (0.0794 mol) of 2,6-dichloropurine in 250 mL of absolute ethanol was added 12.7 mL (0.0873 mol) of triethylamine and 10.62 mL (0.0873 mol) of 4-chlorobenzylamine. The mixture was refluxed at 80° C. for 16 h (the formation of creamy white precipitate was observed). The reaction mixture was cooled and the precipitated product was removed by filtration. The precipitate was washed with ethanol (350 mL) and dried in high vacuum for 24 h. Product was characterized by 1H-NMR.

後処理

  1. temperatureThe reaction mixture was cooled
  2. customthe precipitated product was removed by filtration
  3. washThe precipitate was washed with ethanol (350 mL)
  4. customdried in high vacuum for 24 h

出典と根拠

ORDレコード
ord-925ebb556e1b4c25803035cfbabc0183
出典データセット
uspto-grants-2006_09
特許番号
US07109330B2

反応ノート

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