化工社化工社 化学情報印刷レポート · 研究参考用
Water → 11beta-Methoxy-3-triethylsilyloxy-estra-1,3,5(10),16-tetraene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | Silane, bromotriethyl- | HCID 70680 | — |
| 反応物 | 11beta-Methoxy-estra-1,3,5(10),16-tetraen-3-ol | HCID 69529888 | — |
| 溶媒 | tert-Butyl methyl ether | HCID 15413 | — |
| 生成物 | 11beta-Methoxy-3-triethylsilyloxy-estra-1,3,5(10),16-tetraene | HCID 69529296 | — |
反応手順
284 mg (1 mmol) of 11β-methoxy-estra-1,3,5(10),16-tetraen-3-ol is reacted in 10 ml of tert-butylmethyl ether and 1 ml of pyridine with 0.6 ml of triethylbromosilane. After 1 hour, 30 ml of water is added to the reaction suspension. The organic phase is separated, washed, dried and concentrated by evaporation in a vacuum. The oily product that is thus obtained is used immediately in the next stage (hydroboration). Yield: 380 mg (95% of theory)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07109360B1 |
| 出典データセット | uspto-grants-2006_09 |
| ORD ID | ord-efbeb87e1e2b41fc8d4b3daad033ae6c |
| 出典メモ | uspto-grants-2006_09 |