Chlorosulfonic acid → 4-Amino-3-bromo-5-nitrobenzenesulfonyl chloride

HRID 2216220ノート

反応式

HRID 2216220 の反応式
[NH2:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][C:5]([S:11](N)(=[O:13])=[O:12])=[CH:4][C:3]=1[Br:15].[Cl:16]S(O)(=O)=O>>[NH2:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][C:5]([S:11]([Cl:16])(=[O:13])=[O:12])=[CH:4][C:3]=1[Br:15]

参加物

3

反応物 2

HCID 24638Chlorosulfonic acidHCID 218864374-Amino-3-bromo-5-nitrobenzenesulfonamide

生成物 1

HCID 218861144-Amino-3-bromo-5-nitrobenzenesulfonyl chloride

実験手順

4-Amino-3-bromo-5-nitrobenzenesulfonamide ((U.S. Pat. No. 3,987,199) 1 g, 3.17 mmol) was heated at 95° C. for 3 h in chlorosulfonic acid (10 mL). The solution was cooled then poured onto ice and then filtered. The solid was redissolved in DCM and dried over sodium sulfate. Removal of the solvent yielded the product (960 mg) which was used without further purification.

後処理

  1. temperatureThe solution was cooled
  2. additionthen poured onto ice
  3. filtrationfiltered
  4. dissolutionThe solid was redissolved in DCM
  5. dry with materialdried over sodium sulfate
  6. customRemoval of the solvent

出典と根拠

ORDレコード
ord-607bd1a3adcc4d15a92f53dc37e6714b
出典データセット
uspto-grants-2006_09
特許番号
US07109354B2

反応ノート

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