Neopentyl glycol → 5-Amino-2-(3-hydroxy-2,2-dimethylpropoxy)benzonitrile

HRID 2216397ノート

反応式

HRID 2216397 の反応式
Cl[C:2]1[CH:9]=[CH:8][C:7]([N+:10]([O-])=O)=[CH:6][C:3]=1[C:4]#[N:5].[CH3:13][C:14]([CH3:19])([CH2:17][OH:18])[CH2:15][OH:16]>>[NH2:10][C:7]1[CH:8]=[CH:9][C:2]([O:16][CH2:15][C:14]([CH3:19])([CH3:13])[CH2:17][OH:18])=[C:3]([CH:6]=1)[C:4]#[N:5]

参加物

3

反応物 2

HCID 31344Neopentyl glycolHCID 855042-Chloro-5-nitrobenzonitrile

生成物 1

HCID 219423185-Amino-2-(3-hydroxy-2,2-dimethylpropoxy)benzonitrile収率 59.7%

実験手順

By the reaction and treatment in the same manner as in Starting Material Synthetic Example 2 using 2-chloro-5-nitrobenzonitrile (10 g) and 2,2-dimethyl-1,3-propanediol (5.7 g), the title compound (7.2 g) was obtained. melting point: 194-196° C.

後処理

  1. customBy the reaction and treatment in the same manner as

出典と根拠

ORDレコード
ord-7c1c405a604348d199c9cada26af5d37
出典データセット
uspto-grants-2006_09
特許番号
US07112594B2

反応ノート

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