Sodium Hydroxide → 10-Methoxyiminostilbene
反応式
COC([N:5]1[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[C:9]([O:16][CH3:17])=[CH:8][C:7]2[CH:18]=[CH:19][CH:20]=[CH:21][C:6]1=2)=O.[OH-].[Na+]>O>[CH3:17][O:16][C:9]1[C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[NH:5][C:6]2[CH:21]=[CH:20][CH:19]=[CH:18][C:7]=2[CH:8]=1参加物
4
反応条件
- 温度
- 100 °C
実験手順
A mixture of 10-methoxy-dibenzo[b,f]azepine-5-carboxylic acid methyl ester (19 g, 67.5 mmol), poly (ethylene glycol) 200 (20 ml) and sodium hydroxide solution 50% (13 ml, 246 mmol) is heated to 100° C. for 4hours. Water (30 ml) is added and the suspension is cooled to 20° C. and filtered. The filter cake is washed with water and dried at 60° C./30 mbar to yield 147 g of pure title compound (98%).
後処理
- temperaturethe suspension is cooled to 20° C.
- filtrationfiltered
- washThe filter cake is washed with water
- customdried at 60° C./30 mbar
出典と根拠
- ORDレコード
- ord-d9d9a32b7e9e4358a086f56c91f24cf9
- 出典データセット
- uspto-grants-2006_09
- 特許番号
- US07112673B2
反応ノート
読み込み中…