HCID 20738641、化合物 → (4-Amino-3-methoxy-2-methylphenyl)acetonitrile
反応式
[CH3:1][O:2][C:3]1[C:4]([CH3:15])=[C:5]([CH2:12][C:13]#[N:14])[CH:6]=[CH:7][C:8]=1[N+:9]([O-])=O>C(O)C.[Pd]>[NH2:9][C:8]1[CH:7]=[CH:6][C:5]([CH2:12][C:13]#[N:14])=[C:4]([CH3:15])[C:3]=1[O:2][CH3:1]参加物
4
実験手順
To a solution of (3-methoxy-2-methyl-4-nitro-phenyl)-acetonitrile (1.03 g, 5.0 mmole) in ethanol (100 mL) was added a small amount of 10% palladium on charcoal catalyst and the mixture hydrogenated on the Parr hydrogenator at 45 psi for 3.5 hours. The reaction mixture was filtered through celite and evaporated under reduced pressure to give the (4-amino-3-methoxy-2-methyl-phenyl)acetonitrile as a solid (0.912 g, 100%). 1H NMR (CDCl3) δ: 2.25 (s, 3H), 3.56 (s, 2H), 3.72 (s, 3H), 3.85 (br, 2H), 6.60 (d, 1H, J=8.1 Hz), 6.90 (d, 1H, J=8.1 Hz).
後処理
- filtrationThe reaction mixture was filtered through celite
- customevaporated under reduced pressure
出典と根拠
- ORDレコード
- ord-090c9c94706f4e1a990bf3ccf244d96b
- 出典データセット
- uspto-grants-2008_08
- 特許番号
- US07407980B2
反応ノート
読み込み中…