Chloride → N-(3-fluoro-2'-methanesulfonyl-biphenyl-4-yl)-acrylamide
反応式
[F:1][C:2]1[CH:3]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[S:15]([CH3:18])(=[O:17])=[O:16])[CH:5]=[CH:6][C:7]=1[NH2:8].[C:19]([O-:22])(O)=O.[Na+].[Cl-].[C:25](OCC)(=O)[CH3:26]>>[F:1][C:2]1[CH:3]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[S:15]([CH3:18])(=[O:17])=[O:16])[CH:5]=[CH:6][C:7]=1[NH:8][C:19](=[O:22])[CH:25]=[CH2:26]参加物
5
実験手順
To 3-Fluoro-2′-methanesulfonyl-biphenyl-4-ylamine (8.510 g) in ethyl acetate (400 ml) was added sat. NaHCO3 (100 ml) and then acryolyl chloride (1.3 equiv.). Stirred at room temperature for 3 hours. Washed EtOAc extract with brine, dried over MgSO4 and evaporated in vacuo. Triturated with ether and then filtered to afford N-(3-fluoro-2′-methanesulfonyl-biphenyl-4-yl)-acrylamide (9.670 g, 94%).