Dichloromethane → (2R,4R)-Methyl 4-methoxypyrrolidine-2-carboxylate
反応式
[CH3:1][O:2][C:3]([C@H:5]1[CH2:9][C@@H:8]([O:10][CH3:11])[CH2:7][N:6]1C(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)=[O:4].C(Cl)Cl.C(O)(C(F)(F)F)=O>O>[CH3:1][O:2][C:3]([C@H:5]1[CH2:9][C@@H:8]([O:10][CH3:11])[CH2:7][NH:6]1)=[O:4]参加物
5
実験手順
To a flask containing 3 (4.67 g, 11.6 mmol) was added a solution of CH2Cl2 (27 mL), water (0.3 mL), and TFA (3.0 mL, 38.9 mmol). The solution was stirred at RT for 3 h before concentrating under reduced pressure to reveal impure 4. MS: APCI (AP+): 160.1 (M)+.
後処理
- concentrationbefore concentrating under reduced pressure
出典と根拠
- ORDレコード
- ord-6b15907fb0eb4613ad2b1f357588c084
- 出典データセット
- uspto-grants-2008_08
- 特許番号
- US07407974B2
反応ノート
読み込み中…