Cyclopentanepropanoic acid → N-5-Quinolinyl-cyclopentanepropanamide

HRID 2217814

反応式

HRID 2217814 の反応式
[N:1]1[C:10]2[CH:9]=[CH:8][CH:7]=[C:6]([NH2:11])[C:5]=2[CH:4]=[CH:3][CH:2]=1.[CH:12]1([CH2:17][CH2:18][C:19](O)=[O:20])[CH2:16][CH2:15][CH2:14][CH2:13]1>>[N:1]1[C:10]2[C:5](=[C:6]([NH:11][C:19](=[O:20])[CH2:18][CH2:17][CH:12]3[CH2:16][CH2:15][CH2:14][CH2:13]3)[CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1

参加物

3

反応物 2

HCID 8818Cyclopentanepropanoic acidHCID 119115-Aminoquinoline

生成物 1

HCID 2107517N-5-Quinolinyl-cyclopentanepropanamide収率 24.1%

実験手順

Prepared according to the method of example 18, using 5-quinolinamine (250 mg) and cyclopentanepropanoic acid (270 mg). Purification (HPLC, Symmetry—0.1% aqueous trifluoroacetic acid/acetonitrile) followed by recrystallisation from methanol/ethyl acetate gave the title compound as a colourless solid (112 mg).

後処理

  1. customPrepared
  2. customPurification (HPLC, Symmetry—0.1% aqueous trifluoroacetic acid/acetonitrile)
  3. customfollowed by recrystallisation from methanol/ethyl acetate

出典と根拠

ORDレコード
ord-a80433abb70a48ee91e47047b46d9861
出典データセット
uspto-grants-2008_08
特許番号
US07408065B2

関連ノート

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