Triethylamine → N-[6-Chloro-2-[(3R)-3-hydroxy-1-piperidinyl]-5-quinolinyl]-cyclohexaneacetamide

N-(2,6-Dichloro-5-quinolinyl)-cyclohexaneacetamide (Example 1(a)) (1 g), (3R)-3-piperidinol hydrochloride (0.424 g) and triethylamine (1.2 mL) were placed into a 10 mL microwave vial followed by the addition of acetonitrile (3 mL). The vial was sealed and heated at 120° C. in a single mode microwave for 45 minutes. On cooling a solid crystallised from the reaction mixture which was filtered and washed with acetonitrile (10 mL) to afford the sub-title compound (0.7 g).

1. customThe vial was sealed
2. temperatureOn cooling a solid
3. customcrystallised from the reaction mixture which
4. filtrationwas filtered
5. washwashed with acetonitrile (10 mL)

ORDレコード

ord-e82e0924a146438aafd31e1ac71b3359

出典データセット

uspto-grants-2008_08

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US07408065B2