Sodium Hydroxide → Sodium 5-({3-[2-amino-3-cyano-6-(2-hydroxyphenyl)-4-pyridinyl]phenyl}amino)-4-hydroxy-5-oxopentanoate

HRID 2218250ノート

反応式

HRID 2218250 の反応式
[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([C:10]2[CH:11]=[C:12]([NH:16][C:17]([CH:19]3[CH2:23][CH2:22][C:21](=[O:24])[O:20]3)=[O:18])[CH:13]=[CH:14][CH:15]=2)[CH:5]=[C:4]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=2[OH:31])[N:3]=1.[OH-:32].[Na+:33]>CO>[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([C:10]2[CH:11]=[C:12]([NH:16][C:17](=[O:18])[CH:19]([OH:32])[CH2:23][CH2:22][C:21]([O-:20])=[O:24])[CH:13]=[CH:14][CH:15]=2)[CH:5]=[C:4]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=2[OH:31])[N:3]=1.[Na+:33]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 135469510HCID 135469510、化合物

生成物 1

HCID 136114629Sodium 5-({3-[2-amino-3-cyano-6-(2-hydroxyphenyl)-4-pyridinyl]phenyl}amino)-4-hydroxy-5-oxopentanoate収率 60%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a suspension of N-{3-[2-amino-3-cyano-6-(2-hydroxyphenyl)-4-pyridinyl]phenyl}-5-oxotetrahydro-2-furancarboxamide (0.250 g, 0.603 mmol) in methanol (10 mL) was added dropwise 2N NaOH solution (0.3 mL). After the mixture was stirred for 10 minutes, insoluble solid was filtered off. The filtrate was concentrated under reduced pressure and the residue was crystallized from methanol and ethyl ether. The resulting solid was collected by filtration under an argon atmosphere, washed with ethyl ether, and dried under reduced pressure to give Sodium 5-({3-[2-amino-3-cyano-6-(2-hydroxyphenyl)-4-pyridinyl]phenyl}amino)-4-hydroxy-5-oxopentanoate as a pale yellow solid (0.165 g, yield 60%).

後処理

  1. filtrationinsoluble solid was filtered off
  2. concentrationThe filtrate was concentrated under reduced pressure
  3. customthe residue was crystallized from methanol and ethyl ether
  4. filtrationThe resulting solid was collected by filtration under an argon atmosphere
  5. washwashed with ethyl ether
  6. customdried under reduced pressure

出典と根拠

ORDレコード
ord-c7188f09625f48aeb0a8a93e7c9f4126
出典データセット
uspto-grants-2008_08
特許番号
US07410986B2

反応ノート

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