ethyl (1R,2S)-2-aminocyclohexane-1-carboxylate hydrochloride → Ethyl(1r,2s)-2-aminocyclohexanecarboxylate

反応式

Cl.[CH2:2]([O:4][C:5]([C@@H:7]1[CH2:12][CH2:11][CH2:10][CH2:9][C@@H:8]1[NH2:13])=[O:6])[CH3:3]>[OH-].[Na+]>[CH2:2]([O:4][C:5]([C@@H:7]1[CH2:12][CH2:11][CH2:10][CH2:9][C@@H:8]1[NH2:13])=[O:6])[CH3:3]

参加物

実験手順

Ethyl-cis-2-amino-1-cyclohexanecarboxylate hydrochloride (750 mg) was suspended in 1 N NaOH (pH =12). The aqueous layer was extracted with CH2Cl2, washed with brine, dried over Na2SO4 and evaporated to give the crude ethyl-cis-2-amino- 1-cyclohexanecarboxylate (570 mg).

後処理

extractionThe aqueous layer was extracted with CH2Cl2
washwashed with brine
dry with materialdried over Na2SO4
customevaporated

出典と根拠

ORDレコード: ord-0a8bcbe64fde474dac87d58794b79a2c
出典データセット: uspto-grants-2008_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07411093B2

反応ノート

読み込み中…

参加物

反応物 1

HCID 2724641ethyl (1R,2S)-2-aminocyclohexane-1-carboxylate hydrochloride

生成物 1

HCID 818060Ethyl(1r,2s)-2-aminocyclohexanecarboxylate収率 92.2%

試薬・触媒・溶媒 1

HCID 14798Sodium Hydroxide溶媒

実験手順

後処理

extractionThe aqueous layer was extracted with CH2Cl2
washwashed with brine
dry with materialdried over Na2SO4
customevaporated

出典と根拠

ORDレコード: ord-0a8bcbe64fde474dac87d58794b79a2c
出典データセット: uspto-grants-2008_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07411093B2

反応ノート

読み込み中…