(4-Chloro-3-methoxyphenyl)boronic acid → HCID 68938275、化合物

HRID 2218686

反応式

HRID 2218686 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5](B(O)O)=[CH:4][C:3]=1[O:11][CH3:12].Br[CH:14]=[C:15]1[C:21]2[CH:22]=[CH:23][CH:24]=[C:25]([Cl:26])[C:20]=2[CH2:19][CH2:18][C:17]2[CH:27]=[CH:28][CH:29]=[CH:30][C:16]1=2>>[Cl:26][C:25]1[C:20]2[CH2:19][CH2:18][C:17]3[CH:27]=[CH:28][CH:29]=[CH:30][C:16]=3[C:15](=[CH:14][C:5]3[CH:6]=[CH:7][C:2]([Cl:1])=[C:3]([O:11][CH3:12])[CH:4]=3)[C:21]=2[CH:22]=[CH:23][CH:24]=1

参加物

3

反応物 2

HCID 23005377(4-Chloro-3-methoxyphenyl)boronic acidHCID 688913895-bromomethylene-1-chloro-10,11dihydro-5H-dibenzo[a,d]cycloheptene

生成物 1

HCID 68938275HCID 68938275、化合物収率 71%

実験手順

Following procedures essentially as described in Example 219, below, and using 4-chloro-3-methoxyphenylboronic acid (160 mg,0.85 mmol) with 5-bromomethylene-1-chloro-10,11-dihydro-5H-dibenzo[a,d]cycloheptene (249 mg, 0.78 mmol) to give 440 mg crude product. Purify by chromatography to give 210 mg (71%) colorless oil. HPLC (ISO90-10M) shows 51% at t=7.62 min and 45% at t=9.86 min.

後処理

  1. customto give 440 mg crude product
  2. customPurify by chromatography

出典と根拠

ORDレコード
ord-0ebd9318c8864a898f543e938ac47807
出典データセット
uspto-grants-2008_08
特許番号
US07411072B2

関連ノート

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