Benzoyl Peroxide → 4-Bromoethyl-isophthalic acid dimethylester

HRID 2218937ノート

反応式

HRID 2218937 の反応式
[CH3:1][O:2][C:3](=[O:14])[C:4]1C=CC(C)=C(C(O)=O)[CH:5]=1.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1.[Br:33]N1C(=O)CCC1=O.C[CH2:42][CH2:43][CH2:44][CH2:45][CH3:46].C[CH2:48][O:49][C:50]([CH3:52])=[O:51]>C(Cl)(Cl)(Cl)Cl>[CH3:48][O:49][C:50](=[O:51])[C:52]1[CH:46]=[CH:45][C:44]([CH2:43][CH2:42][Br:33])=[C:4]([C:3]([O:2][CH3:1])=[O:14])[CH:5]=1

参加物

6

反応物 4

HCID 7187Benzoyl PeroxideHCID 67184N-bromobutanimideHCID 21226206Ethyl acetate hexaneHCID 229994865-(Methoxycarbonyl)-2-methylbenzoic acid

生成物 1

HCID 537536654-Bromoethyl-isophthalic acid dimethylester

試薬・触媒・溶媒 1

HCID 5943Carbon Tetrachloride溶媒

実験手順

A mixture of (4) (0.96 g, 4.61 mmol), dibenzoylperoxide (56 mg, 0.23 mmol) and N-bromosuccinimide (NBS) (0.82 g, 4.61 mmol) in carbon tetrachloride (20 ml) was heated at reflux for 20 hours. After cooling to room temperature and filteration the solvent was evaporated to give a yellow oil. Flash chromatograph: silica, hexane/EtOAc (7:3) afforded the pure compound.

後処理

  1. temperaturewas heated
  2. temperatureat reflux for 20 hours
  3. customfilteration the solvent was evaporated
  4. customto give a yellow oil

出典と根拠

ORDレコード
ord-6f4713bd9ddb44dd955be17255b13fbc
出典データセット
uspto-grants-2008_08
特許番号
US07413727B2

反応ノート

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