Sulfuric Acid → 61706-47-6

HRID 2219082ノート

反応式

HRID 2219082 の反応式
[N+:1]([C:4]1[CH:19]=[CH:18][C:7]([C:8]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)([CH3:11])[C:9]#[N:10])=[CH:6][CH:5]=1)([O-:3])=[O:2].S(=O)(=O)(O)[OH:21].[OH-].[Na+]>>[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([C:8]([C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)([CH3:11])[C:9]([NH2:10])=[O:21])=[CH:18][CH:19]=1)([O-:3])=[O:2]

参加物

4

反応物 3

HCID 1118Sulfuric AcidHCID 14798Sodium HydroxideHCID 2110592-(4-Nitrophenyl)-2-phenylpropanenitrile

生成物 1

HCID 304617961706-47-6

実験手順

) A mixture of 0.020 mol of p-nitro-α-phenylhydratroponitrile and 28 ml of concentrated sulfuric acid solution (90%) is heated in a water-bath for 3.5 hours. The reaction mixture is poured onto crushed ice, neutralized with a sodium hydroxide solution and the product is extracted with chloroform. The organic layer is washed with water, dried and evaporated in vacuo and the residue is crystallized from ether, yielding 2.4 grams of p-nitro-α-phenylhydratropamide. (interm. 7)

後処理

  1. temperatureis heated in a water-bath for 3.5 hours
  2. additionThe reaction mixture is poured
  3. customonto crushed ice
  4. extractionthe product is extracted with chloroform
  5. washThe organic layer is washed with water
  6. customdried
  7. customevaporated in vacuo
  8. customthe residue is crystallized from ether

出典と根拠

ORDレコード
ord-84c90870540c4400978c5e456b8b41ca
出典データセット
uspto-grants-2008_08
特許番号
US07414048B2

反応ノート

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