Lithium hydroxide, monohydrate → 5-Ethyl-3-phenyl-1,2-oxazole-4-carboxylic acid
反応式
C[O:2][C:3]([C:5]1[C:6]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[N:7][O:8][C:9]=1[CH2:10][CH3:11])=[O:4].O[Li].O>C1COCC1.O>[CH2:10]([C:9]1[O:8][N:7]=[C:6]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:5]=1[C:3]([OH:4])=[O:2])[CH3:11]参加物
5
実験手順
To a solution of 5-ethyl-3-phenyl-isoxazole-4-carboxylic acid methyl ester (12.0 g, 51 mmol) in THF (50 mL), was added a solution of LiOH.H2O (10.8 g, 255 mmol) in water (25 mL) in one portion. The reaction mixture was then heated under reflux for 12 h. After cooling to room temperature and concentration, the remaining mixture was extracted with ethyl acetate and dried over sodium sulphate. Evaporation afforded the title compound (8.01 g, 72%) as yellow solid. MS: m/e=218.1 [M+H]+.
後処理
- temperatureThe reaction mixture was then heated
- temperatureunder reflux for 12 h
- concentrationconcentration
- extractionthe remaining mixture was extracted with ethyl acetate
- dry with materialdried over sodium sulphate
- customEvaporation
出典と根拠
- ORDレコード
- ord-4877205193f3444d989c7ce319d59308
- 出典データセット
- uspto-grants-2008_08
- 特許番号
- US07414061B2
反応ノート
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