化工社化工社 化学情報印刷レポート · 研究参考用
Water → ((4-Cyclohexylphenoxy)methyl)oxirane
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Cesium carbonate | HCID 10796 | — |
| 反応物 | 4-Cyclohexylphenol | HCID 14327 | — |
| 反応物 | (-)-Epichlorohydrin | HCID 2734062 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | ((4-Cyclohexylphenoxy)methyl)oxirane | HCID 5743581 | — |
反応手順
To a mixture of R-epichlorohydrin (9.8 g, 106 mmol) and 4-cyclohexylphenol (3.73 g, 21.2 mmol) in acetonitrile (40 ml) was added cesium carbonate (6.9 g, 21.2 mmol). The mixture was heated at reflux for 3 hours. The reaction mixture was cooled, poured into water (100 mL) and extracted twice with EtOAc. The organic phases were combined and washed with water, brine, dried (Na2SO4), concentrated and dried under high vacuum overnight to give the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08207181B2 |
| 出典データセット | uspto-grants-2012_06 |
| ORD ID | ord-d3037173a1b8480bbbcf4512227dd842 |
| 出典メモ | uspto-grants-2012_06 |