Ammonium Hydroxide → 3-(4-Bromophenyl)propanamide
反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][C:10]([OH:12])=O)=[CH:4][CH:3]=1.[OH-].[NH4+:14]>S(Cl)(Cl)=O.CN(C)C=O>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][C:10]([NH2:14])=[O:12])=[CH:4][CH:3]=1参加物
5
実験手順
To a solution of 3-(4-bromophenyl)propanoic acid (15.0 g) in thionyl chloride (24.5 g) was added catalytic amount of N,N-dimethylformamide (one drop) and refluxed for 1.5 hours under nitrogen atmosphere. After cooling to room temperature, the reaction mixture was poured slowly into 28% aqueous ammonium hydroxide solution (150 ml) at 0° C. The mixture was extracted with ethyl acetate, washed with water and brine and dried over magnesium sulfate. Filtration followed by evaporation under reduced pressure gave 3-(4-bromophenyl)propanamide (13.7 g) as a white solid.
後処理
- temperaturerefluxed for 1.5 hours under nitrogen atmosphere
- extractionThe mixture was extracted with ethyl acetate
- washwashed with water and brine
- dry with materialdried over magnesium sulfate
- filtrationFiltration
- customfollowed by evaporation under reduced pressure
出典と根拠
- ORDレコード
- ord-12f1080491fe4e489b0dd82f8ea8d25e
- 出典データセット
- uspto-grants-2008_08
- 特許番号
- US07417060B2
反応ノート
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