Water → Ethyl 4-benzyloxy-2-ethylbenzoate

HRID 2220614ノート

反応式

HRID 2220614 の反応式
[CH2:1](I)[CH3:2].[CH2:4]([O:11][C:12]1[CH:20]=[CH:19][C:15]([C:16]([OH:18])=[O:17])=[C:14]([CH2:21][CH3:22])[CH:13]=1)[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.C(=O)([O-])[O-].[K+].[K+].O>CN(C)C=O>[CH2:4]([O:11][C:12]1[CH:20]=[CH:19][C:15]([C:16]([O:18][CH2:1][CH3:2])=[O:17])=[C:14]([CH2:21][CH3:22])[CH:13]=1)[C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=1

参加物

6

反応物 4

HCID 962WaterHCID 6340IodoethaneHCID 11430Potassium CarbonateHCID 231341484-(Benzyloxy)-2-ethylbenzoic acid

生成物 1

HCID 23134224Ethyl 4-benzyloxy-2-ethylbenzoate

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

Ethyl iodide (0.268 mL) was added to a suspension of 4-benzyloxy-2-ethylbenzoic acid (0.572 g) and potassium carbonate (0.617 g) in N,N-dimethylformamide (5.6 mL) at room temperature with stirring. The mixture was stirred at 50° C. for 1.5 hrs and at room temperature for 13 hrs, and then water was added. The mixture was extracted with ethyl acetate. The organic layer was washed with water, an aqueous solution of sodium chloride and brine successively, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to afford the title compound (0.635 g).

後処理

  1. stirringThe mixture was stirred at 50° C. for 1.5 hrs and at room temperature for 13 hrs
  2. extractionThe mixture was extracted with ethyl acetate
  3. washThe organic layer was washed with water
  4. dry with materialan aqueous solution of sodium chloride and brine successively, and dried over anhydrous magnesium sulfate
  5. customThe solvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-19787cdd1bf64b5e9d3e95d4b6938e04
出典データセット
uspto-grants-2008_08
特許番号
US07417169B2

反応ノート

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