1-tert-Butoxycarbonyl-3-methoxycarbonyl-5-nitropyrazole → 5-Amino-1-tert-butoxycarbonyl-3-methoxycarbonylpyrazole

HRID 2220729ノート

反応式

HRID 2220729 の反応式
[C:1]([O:5][C:6]([N:8]1[C:12]([N+:13]([O-])=O)=[CH:11][C:10]([C:16]([O:18][CH3:19])=[O:17])=[N:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[H][H]>[Pd]>[NH2:13][C:12]1[N:8]([C:6]([O:5][C:1]([CH3:2])([CH3:3])[CH3:4])=[O:7])[N:9]=[C:10]([C:16]([O:18][CH3:19])=[O:17])[CH:11]=1

参加物

4

反応物 2

HCID 597735771-tert-Butoxycarbonyl-3-methoxycarbonyl-5-nitropyrazoleHCID 178418361HCID 178418361、化合物

生成物 1

HCID 597733355-Amino-1-tert-butoxycarbonyl-3-methoxycarbonylpyrazole

試薬・触媒・溶媒 1

HCID 23938Palladium触媒

実験手順

A mixture of 1.0 eq. of 19 and 0.1 wt/wt eq. of 10% Pd on carbon was hydrogenated at 10-60 psi of hydrogen for a time sufficient for reaction completion. The reaction mixture was filtered through Celite. The filtrate was concentrated by rotary evaporation. The crude material was dried under vacuum to give product 20.

後処理

  1. filtrationThe reaction mixture was filtered through Celite
  2. concentrationThe filtrate was concentrated by rotary evaporation
  3. dry with materialThe crude material was dried under vacuum

出典と根拠

ORDレコード
ord-ffe1a76027e44d158fe4ca868a5f6ba5
出典データセット
uspto-grants-2008_08
特許番号
US07417152B2

反応ノート

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