Hydrochloric Acid → HCID 178524563、化合物
反応式
[Cl:1][C:2]1[CH:19]=[CH:18][CH:17]=[CH:16][C:3]=1[C:4]([NH:6][C:7]1[NH:11][N:10]=[C:9]([C:12]([O:14]C)=[O:13])[CH:8]=1)=[O:5].O[Li].O.O.Cl>C1COCC1.CO>[Cl:1][C:2]1[CH:19]=[CH:18][CH:17]=[CH:16][C:3]=1[C:4]([NH:6][C:7]1[NH:11][N:10]=[C:9]([C:12]([OH:14])=[O:13])[CH:8]=1)=[O:5]参加物
7
実験手順
A solution of 1.0 eq. of 22 and 5.0 eq. of LiOH.H2O in THF, MeOH, and H2O (2:1:1) was stirred at rt. After a time sufficient for reaction completion, the reaction mixture was rotary evaporated. The mixture was acidified with concentrated HCl. As the pH of the solution reached about 2, a precipitate formed. The solid was collected by filtration and after drying under vacuum, product 23 was obtained.
後処理
- customAfter a time sufficient for reaction completion
- customa precipitate formed
- filtrationThe solid was collected by filtration
- customafter drying under vacuum
出典と根拠
- ORDレコード
- ord-287c2dc85353442fac8e191772b4028d
- 出典データセット
- uspto-grants-2008_08
- 特許番号
- US07417152B2
反応ノート
読み込み中…