Lithium Hydroxide → Benzoic Acid

HRID 2220732ノート

反応式

HRID 2220732 の反応式
C[O:2][C:3](=[O:22])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1CSC1C=CC=C2C=1N=CC=C2.[Li+].[OH-]>CO.O>[C:3]([OH:22])(=[O:2])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

参加物

5

反応物 2

HCID 3939Lithium HydroxideHCID 59773474HCID 59773474、化合物

生成物 1

HCID 243Benzoic Acid

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

A solution of 1.0 eq of ester 41 and 3.0 eq. of LiOH in methanol and water was heated to 65° C. for a time sufficient for completion of the hydrolysis. The mixture was cooled to room temperature and concentrated, then diluted with H2O. The pH of the aqueous mixture was adjusted to 4.5 and extracted with EtOAc. The organic layer was washed with brine and dried over Na2SO4, filtered, and concentrated to give the intermediate benzoic acid.

後処理

  1. concentrationconcentrated
  2. additiondiluted with H2O
  3. extractionextracted with EtOAc
  4. washThe organic layer was washed with brine
  5. dry with materialdried over Na2SO4
  6. filtrationfiltered
  7. concentrationconcentrated

出典と根拠

ORDレコード
ord-ec22f5c9214a43ce9452d43aec77d015
出典データセット
uspto-grants-2008_08
特許番号
US07417152B2

反応ノート

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