2-Oxo-[1,4']bipiperidinyl-1'-carboxylic acid benzyl ester → [1,4'-Bipiperidin]-2-one

HRID 2221081ノート

反応式

HRID 2221081 の反応式
C(OC([N:11]1[CH2:16][CH2:15][CH:14]([N:17]2[CH2:22][CH2:21][CH2:20][CH2:19][C:18]2=[O:23])[CH2:13][CH2:12]1)=O)C1C=CC=CC=1>[OH-].[OH-].[Pd+2].C(O)C>[N:17]1([CH:14]2[CH2:15][CH2:16][NH:11][CH2:12][CH2:13]2)[CH2:22][CH2:21][CH2:20][CH2:19][C:18]1=[O:23]

参加物

4

反応物 1

HCID 233699802-Oxo-[1,4']bipiperidinyl-1'-carboxylic acid benzyl ester

生成物 1

HCID 21839852[1,4'-Bipiperidin]-2-one

試薬・触媒・溶媒 2

HCID 9942167Palladium hydroxide触媒HCID 702Ethanol溶媒

実験手順

2-Oxo-[1,4′]bipiperidinyl-1′-carboxylic acid benzyl ester (2.5 g) and Pearlman's catalyst (0.50 g) was stirred in ethanol (30 mL) under hydrogen (1 atm). After 20 hours the reaction as filtered through celite and concentrated. The title compound was obtained as a white solid (1.45 g). MS: m/z=183 (M+H).

後処理

  1. customAfter 20 hours the reaction
  2. filtrationas filtered through celite and
  3. concentrationconcentrated

出典と根拠

ORDレコード
ord-cad510d22ef144e9bbc92fbeab35ec16
出典データセット
uspto-grants-2008_05
特許番号
US07368461B2

反応ノート

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