(3-benzyloxy-1-phenyl-1H-pyrazol-5-yl)methanol → HCID 22930766、化合物

HRID 2221612ノート

反応式

HRID 2221612 の反応式
[CH2:1]([O:8][C:9]1[CH:13]=[C:12]([CH2:14][OH:15])[N:11]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>[O-2].[O-2].[Mn+4].O1CCCC1>[CH2:1]([O:8][C:9]1[CH:13]=[C:12]([CH:14]=[O:15])[N:11]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[N:10]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

4

反応物 1

HCID 22930692(3-benzyloxy-1-phenyl-1H-pyrazol-5-yl)methanol

生成物 1

HCID 22930766HCID 22930766、化合物収率 91%

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 8028Tetrahydrofuran溶媒

実験手順

A mixture of (3-benzyloxy-1-phenyl-1H-pyrazol-5-yl)methanol (11.20 g), activated manganese dioxide (30.00 g) and tetrahydrofuran (300 mL) was stirred overnight at room temperature. The insoluble material was removed by filtration, and the mother liquid was concentrated. The residue was subjected to silica gel column chromatography to give 3-benzyloxy-1-phenyl-1H-pyrazole-5-carbaldehyde (10.10 g, yield 91%) as a pale-yellow oil from a fraction eluted with ethyl acetate-hexane (1:2, v/v).

後処理

  1. customThe insoluble material was removed by filtration
  2. concentrationthe mother liquid was concentrated

出典と根拠

ORDレコード
ord-4e3ba7244554440e8361a27aae44d5df
出典データセット
uspto-grants-2008_05
特許番号
US07368578B2

反応ノート

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