(3-amino-1-phenyl-1H-pyrazol-4-yl)methanol → 3-amino-1-phenyl-1H-pyrazole-4-carbaldehyde
反応式
[NH2:1][C:2]1[C:6]([CH2:7][OH:8])=[CH:5][N:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[N:3]=1>[O-2].[O-2].[Mn+4].O1CCCC1>[NH2:1][C:2]1[C:6]([CH:7]=[O:8])=[CH:5][N:4]([C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=2)[N:3]=1参加物
4
実験手順
A mixture of (3-amino-1-phenyl-1H-pyrazol-4-yl)methanol (12.29 g), activated manganese dioxide (35 g) and tetrahydrofuran (200 mL) was stirred at room temperature for 16 hrs. The reaction mixture was filtered, and the filtrate was concentrated. Recrystallization of the residue from tetrahydrofuran-hexane gave 3-amino-1-phenyl-1H-pyrazole-4-carbaldehyde as pale-yellow crystals (10.02 g, yield 82%). melting point: 129-130° C.
後処理
- filtrationThe reaction mixture was filtered
- concentrationthe filtrate was concentrated
- customRecrystallization of the residue from tetrahydrofuran-hexane
出典と根拠
- ORDレコード
- ord-beb7c6aaacdc48baa96767af1f113749
- 出典データセット
- uspto-grants-2008_05
- 特許番号
- US07368578B2
反応ノート
読み込み中…