Sodium sulfate decahydrate → (1-ethyl-1H-imidazol-4-yl)methanol

HRID 2221657ノート

反応式

HRID 2221657 の反応式
[H-].[Al+3].[Li+].[H-].[H-].[H-].[CH2:7]([N:9]1[CH:13]=[C:12]([CH:14]=[O:15])[N:11]=[CH:10]1)[CH3:8].O.O.O.O.O.O.O.O.O.O.S([O-])([O-])(=O)=O.[Na+].[Na+]>O1CCCC1>[CH2:7]([N:9]1[CH:13]=[C:12]([CH2:14][OH:15])[N:11]=[CH:10]1)[CH3:8]

参加物

5

反応物 3

HCID 62649Sodium sulfate decahydrateHCID 135098721-Ethyl-1H-imidazole-4-carbaldehydeHCID 21226445Aluminium lithium hydride

生成物 1

HCID 18361866(1-ethyl-1H-imidazol-4-yl)methanol収率 100.5%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a mixture of lithium aluminum hydride (1.74 g) and tetrahydrofuran (100 mL) was added 1-ethyl-1H-imidazole-4-carbaldehyde (5.71 g) at 0° C. After stirring the reaction mixture for 1 hr, sodium sulfate decahydrate (15 g) was added and the mixture was further stirred at room temperature for 5 hrs. Insoluble materials were filtered off and the filtrate was concentrated to give (1-ethyl-1H-imidazol-4-yl)methanol as a colorless oil (5.83 g, yield 100%).

後処理

  1. stirringthe mixture was further stirred at room temperature for 5 hrs
  2. filtrationInsoluble materials were filtered off
  3. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-8caadaffb4f7429aa5e81f7717f2044a
出典データセット
uspto-grants-2008_05
特許番号
US07368578B2

反応ノート

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