3-Chloro-2-nitrobenzoic acid → N-(diethylphosphonomethyl)-2-nitro-3-chlorobenzamide

HRID 2222111

反応式

HRID 2222111 の反応式
[Cl:1][C:2]1[C:3]([N+:11]([O-:13])=[O:12])=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5]([OH:7])=O.[PH:14]1(=[O:23])[O:21][CH2:20][CH2:19]C(N)[CH2:17][CH2:16][O:15]1.[CH:24]([N:27](C(C)C)CC)(C)C>ClCCl>[CH2:20]([O:21][P:14]([CH2:24][NH:27][C:5](=[O:7])[C:4]1[CH:8]=[CH:9][CH:10]=[C:2]([Cl:1])[C:3]=1[N+:11]([O-:13])=[O:12])([O:15][CH2:16][CH3:17])=[O:23])[CH3:19]

参加物

5

反応物 3

HCID 209023-Chloro-2-nitrobenzoic acidHCID 81531DiisopropylethylamineHCID 178507970HCID 178507970、化合物

生成物 1

HCID 57457785N-(diethylphosphonomethyl)-2-nitro-3-chlorobenzamide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of 3-chloro-2-nitrobenzoic acid (1 mmol) and aminomethylenediethyl phosphonate (1.1 mmol) in dichloromethane (5 mL) was added diisopropylethylamine (5 mmol) followed by pyBOP (1.5 mmol). The reaction was stirred at room temperature for 3 h and concentrated. The mixture was purified by chromatography to yield N-(diethylphosphonomethyl)-2-nitro-3-chlorobenzamide as a solid.

後処理

  1. concentrationconcentrated
  2. customThe mixture was purified by chromatography

出典と根拠

ORDレコード
ord-b600187e708946b089bdc25769d32996
出典データセット
uspto-grants-2008_05
特許番号
US07371739B2

関連ノート

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