Ethylenediamine → N-(1-methyl-4-pyrazolylmethyl)trimethylenediamine

At room temperature 11 g of 1-methyl-4-pyrazole carbaldehyde was slowly added to 37 g of ethylenediamine in 150 ml of dry acetonitrile. Molecular sieves 4A (a product of Wako Pure Chemicals, Co.) were added as a dehydrating agent to the solution. The mixture was stirred at room temperature for 2 hours, and filtered. Acetonitrile was distilled off under reduced pressure from the filtrate. To the residue was added 100 ml of ethanol, and then 4 g of sodium borohydride was added little by little at room temperature. The mixture was then stirred at room temperature for 2 hours, and ethanol was distilled off under reduced pressure. Water was added to the residue, and the mixture was extracted with dichloromethane. The solvent was distilled off from the dichloromethane layer, and the residue was vacuum-distilled to give 10 g of N-(1-methyl-4-pyrazolylmethyl)trimethylenediamine as a colorless oil.

1. addition) were added as a dehydrating agent to the solution
2. filtrationfiltered
3. distillationAcetonitrile was distilled off under reduced pressure from the filtrate
4. additionTo the residue was added 100 ml of ethanol
5. addition4 g of sodium borohydride was added little by little at room temperature
6. stirringThe mixture was then stirred at room temperature for 2 hours
7. distillationethanol was distilled off under reduced pressure
8. additionWater was added to the residue
9. extractionthe mixture was extracted with dichloromethane
10. distillationThe solvent was distilled off from the dichloromethane layer
11. distillationthe residue was vacuum-distilled

ORDレコード

ord-5caca19306454786a9c1ccfcb92220c8

出典データセット

uspto-grants-1995_06

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US05428032