(Z)-2-(3,4-dimethoxyphenyl)-3-(4-hydroxyphenyl)acrylonitrile → 4-[(Z)-2-cyano-2-(3,4-dimethoxy-phenyl)-vinyl]-phenyl ethyl succinate

HRID 2222363ノート

反応式

HRID 2222363 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5](/[C:11](=[CH:14]/[C:15]2[CH:20]=[CH:19][C:18]([OH:21])=[CH:17][CH:16]=2)/[C:12]#[N:13])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].[Cl-].[CH2:23]([O:25][C:26](=[O:32])[CH2:27][CH2:28][C:29](O)=[O:30])[CH3:24]>N1C=CC=CC=1>[C:29]([O:21][C:18]1[CH:17]=[CH:16][C:15](/[CH:14]=[C:11](\[C:12]#[N:13])/[C:5]2[CH:6]=[CH:7][C:8]([O:9][CH3:10])=[C:3]([O:2][CH3:1])[CH:4]=2)=[CH:20][CH:19]=1)(=[O:30])[CH2:28][CH2:27][C:26]([O:25][CH2:23][CH3:24])=[O:32]

参加物

4

反応物 2

HCID 10446442(Z)-2-(3,4-dimethoxyphenyl)-3-(4-hydroxyphenyl)acrylonitrileHCID 77519041Succinic acid monoethyl ester monochloride

生成物 1

HCID 100471094-[(Z)-2-cyano-2-(3,4-dimethoxy-phenyl)-vinyl]-phenyl ethyl succinate収率 90%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

Compound 1 (50 mg) and succinic acid monoethyl ester chloride (51 μL) were dissolved in pyridine (1 mL), followed by stirring for a whole day and night. After completion of reaction, the resultant reaction mixture was concentrated to dryness under reduced pressure, followed by purification by means of silica gel chromatography employing a chloroform/methanol system, to thereby produce the target product (73 mg, yield: 90%).

後処理

  1. customAfter completion of reaction
  2. customthe resultant reaction mixture
  3. concentrationwas concentrated to dryness under reduced pressure
  4. customfollowed by purification by means of silica gel chromatography

出典と根拠

ORDレコード
ord-4d29862f1a6a4a93b96a61d3ba7b81fd
出典データセット
uspto-grants-2008_05
特許番号
US07371773B2

反応ノート

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